Dock9 Gene Summary [Mouse]
Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in positive regulation of GTPase activity. Predicted to be located in endomembrane system and membrane. Is expressed in extraembryonic component; forelimb bud; forelimb bud mesenchyme; and neocortex. Orthologous to human DOCK9 (dedicator of cytokinesis 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dock9 |
| Official Name | dedicator of cytokinesis 9 [Source:MGI Symbol;Acc:MGI:106321] |
| Ensembl ID | ENSMUSG00000025558 |
| Bio databases IDs | |
| Aliases | dedicator of cytokinesis 9 |
| Synonyms | B230309H04Rik, D14Wsu89e, dedicator of cytokinesis 9, KIAA1085, mKIAA1058, Trg, ZIZ1, ZIZIMIN1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dock9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DHR-2, Lobe B
- C2 domain in Dock180 and Zizimin proteins
- DHR-2, Lobe A
- enzyme binding
- protein binding
- Pleckstrin homology-like domain
- CDM-zizimin homology domain
- Dedicator of cytokinesis C/D, N terminal
- Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins
- guanyl-nucleotide exchange factor
- PH domain
- C2 domain
- DHR-2, Lobe C
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pelvic organ prolapse
- cervical cancer
- Moyamoya disease
- myopia
- progressive vision loss
- irritable bowel syndrome
- corneal astigmatism
role in cell
- expression in
- apoptosis
- activation in
- proliferation
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dock9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- small GTPase mediated signal transduction
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- membrane
- endomembrane system
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding
- guanyl-nucleotide exchange factor activity