Pde8a Gene Summary [Mouse]
Enables 3',5'-cyclic-AMP phosphodiesterase activity. Involved in cellular response to epidermal growth factor stimulus and positive regulation of ERK1 and ERK2 cascade. Is expressed in several structures, including genitourinary system; gut gland; integumental system; nervous system; and skeleton. Orthologous to human PDE8A (phosphodiesterase 8A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pde8a |
| Official Name | phosphodiesterase 8A [Source:MGI Symbol;Acc:MGI:1277116] |
| Ensembl ID | ENSMUSG00000025584 |
| Bio databases IDs | |
| Aliases | phosphodiesterase 8A |
| Synonyms | HsT19550, Pde8, phosphodiesterase 8A, RNPDE8A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pde8a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- 3'5'-cyclic nucleotide phosphodiesterase
- kinase binding
- 3',5'-cyclic-GMP phosphodiesterase
- PAS domain
- PAS domain S-box
- cAMP-specific phosphodiesterase
- PAS
- enzyme
- HDc
- PAS fold
- 3',5'-cyclic-nucleotide phosphodiesterase
Pathways
Biological processes and signaling networks where the Pde8a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- infection
- HIV infection
- cardiovascular disorder
- hepatic fibrosis
- obesity
- diabetes mellitus
- pulmonary hypertensive arterial disease
- non-bulky Hodgkin lymphoma
- acute kidney injury
role in cell
- expression in
- phosphorylation in
- production in
- activation in
- steroidogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- Plasma Membrane
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pde8a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of ERK1 and ERK2 cascade
- cellular response to epidermal growth factor stimulus
- regulation of transcription, DNA-dependent
- cAMP catabolic process
- cAMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- protein kinase activator activity
- 3',5'-cyclic-GMP phosphodiesterase activity
- kinase binding
- 3',5'-cyclic-AMP phosphodiesterase activity