Thoc3 Gene Summary [Mouse]
Predicted to enable RNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to be located in nuclear speck. Predicted to be part of THO complex part of transcription export complex. Predicted to colocalize with chromosome, telomeric region. Is expressed in brain. Orthologous to human THOC3 (THO complex subunit 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Thoc3 |
| Official Name | THO complex 3 [Source:MGI Symbol;Acc:MGI:1920916] |
| Ensembl ID | ENSMUSG00000025872 |
| Bio databases IDs | |
| Aliases | THO complex 3 |
| Synonyms | 2410044K02RIK, AL033344, hTREX45, THO3, THO complex 3, THO complex subunit 3, TREX45 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Thoc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spliceosomes
- nucleoplasm
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Thoc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- RNA splicing
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nuclear speck
- transcription export complex
- THO complex part of transcription export complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding