Thoc6 Gene Summary [Mouse]
Predicted to enable RNA binding activity. Predicted to be involved in central nervous system development and mRNA export from nucleus. Predicted to be located in nuclear speck. Predicted to be part of THO complex part of transcription export complex. Predicted to colocalize with chromosome, telomeric region. Is expressed in brain; embryo; and future forebrain. Orthologous to human THOC6 (THO complex subunit 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Thoc6 |
| Official Name | THO complex 6 [Source:MGI Symbol;Acc:MGI:2677480] |
| Ensembl ID | ENSMUSG00000041319 |
| Bio databases IDs | |
| Aliases | THO complex 6 |
| Synonyms | F830014G06Rik, fSAP35, MMRFCGU, Pdrp, THO complex 6, THO complex subunit 6, TREX40, WDR58 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Thoc6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cellular membrane
- spliceosomes
- nucleoplasm
- nuclear bodies
- nuclear speckles
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Thoc6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- RNA splicing
- central nervous system development
- apoptotic process
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- nuclear body
- nuclear speck
- THO complex
- THO complex part of transcription export complex
- transcription export complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding