Inpp4a Gene Summary [Mouse]
Predicted to enable phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including cranium; facial prominence ectoderm; integumental system; nervous system; and urinary system. Orthologous to human INPP4A (inositol polyphosphate-4-phosphatase type I A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Inpp4a |
| Official Name | inositol polyphosphate-4-phosphatase, type I [Source:MGI Symbol;Acc:MGI:1931123] |
| Ensembl ID | ENSMUSG00000026113 |
| Bio databases IDs | |
| Aliases | inositol polyphosphate-4-phosphatase, type I |
| Synonyms | 105kda 4-phosphatase, 9630012D15, D130048C09RIK, inositol polyphosphate-4-phosphatase, type I, inositol polyphosphate-4-phosphatase type I A, INOSITOL POLYPHOSPHATE 4 PHOSPHATASE type I beta, INOSITOL POLYPHOSPHATE 4 PHOSPHATASE type I β, INPP4, R74740, TVAS1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Inpp4a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- inositol-1,3,4-trisphosphate 4-phosphatase
- inositol bisphosphate phosphatase
- phosphatase
- protein binding
- phosphatidylinositol-3,4-bisphosphate 4-phosphatase
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodegeneration
- bipolar disorder
- autosomal dominant dyskeratosis congenita type 1
- mental retardation
- autosomal recessive nonsyndromic mental retardation
- stuttering
role in cell
- apoptosis
- phosphorylation in
- migration
- cell death
- growth
- number
- survival
- signaling in
- motility
- localization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- perinuclear region
- Nucleus
- cytosol
- nucleoplasm
- nuclear envelope
- nerve ending
- early endosomes
- peri-Golgi vesicles
- perinuclear vesicles
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Inpp4a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inositol phosphate metabolic process
- signal transduction
- phosphatidylinositol-3-phosphate biosynthetic process
- phosphatidylinositol biosynthetic process
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- nucleus
- postsynaptic density
- nuclear membrane
- cytoplasm
- cytosol
- recycling endosome membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
- protein binding
- inositol-1,3,4-trisphosphate 4-phosphatase activity
- inositol-3,4-bisphosphate 4-phosphatase activity