Trp53bp2 Gene Summary [Mouse]
Predicted to enable NF-kappaB binding activity; p53 binding activity; and protein homodimerization activity. Acts upstream of or within several processes, including embryo development; heart development; and response to ionizing radiation. Predicted to be located in cell junction and cytosol. Predicted to be active in nucleus. Predicted to colocalize with perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and urinary system. Used to study chromosome 1q41-q42 deletion syndrome. Orthologous to human TP53BP2 (tumor protein p53 binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trp53bp2 |
| Official Name | transformation related protein 53 binding protein 2 [Source:MGI Symbol;Acc:MGI:2138319] |
| Ensembl ID | ENSMUSG00000026510 |
| Bio databases IDs | |
| Aliases | transformation related protein 53 binding protein 2 |
| Synonyms | 53BP2, ASPP2, p53-Binding, P53BP2, PPP1R13A, transformation related protein 53 binding protein 2, Trp53bp2, tumor protein p53 binding protein 2, tumor protein p53 binding protein, 2, tumour protein p53 binding protein 2, tumour protein p53 binding protein, 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trp53bp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Coiled-coil region of CCDC155 or KASH
- Ankyrin repeats (many copies)
- NF-kappaB binding
- Ankyrin repeats (3 copies)
- p53 binding
- protein binding
- proline rich domain
- identical protein binding
- proline tyrosine motif
- Ankyrin repeat
- Src Homology 3 domain superfamily
- Ubl1_cv_Nsp3_N-like
- Growth-arrest specific micro-tubule binding
- protein homodimerization
- ankyrin repeats
Pathways
Biological processes and signaling networks where the Trp53bp2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- neuroinflammation
- peripheral arterial disease
- metastasis
- multiple sclerosis
- encephalitis
- open-angle glaucoma
- systemic lupus erythematosus
phenotypes
- embryonic lethality prior to organogenesis
- embryonic lethality prior to tooth bud stage
- preweaning lethality complete penetrance
- abnormal T cell physiology
- abnormal brain morphology
- abnormal cell cycle checkpoint function
- abnormal cerebral cortex morphology
- abnormal choroid plexus morphology
- abnormal cortical plate morphology
- abnormal cortical ventricular zone morphology
- abnormal dorsal root ganglion morphology
- abnormal embryonic neuroepithelial cell proliferation
- abnormal embryonic neuroepithelium morphology
- abnormal embryonic/fetal subventricular zone morphology
- abnormal gait
- abnormal heart position or orientation
- abnormal lateral ventricle morphology
- abnormal neural tube morphology
- abnormal neuron differentiation
- abnormal neuronal migration
- abnormal neuronal precursor proliferation
- abnormal olfactory bulb morphology
- abnormal pineal gland morphology
- abnormal retina morphology
- abnormal retinal outer nuclear layer morphology
- abnormal retinal photoreceptor layer morphology
- abnormal retinal progenitor cell morphology
- abnormal sex gland morphology
- abnormal spinal cord central canal morphology
- abnormal stratification in cerebral cortex
- abnormal trigeminal nerve morphology
- abnormal urethra morphology
- absent abducens nerve
- absent pineal gland
- anophthalmia
- cleft palate
- coloboma
- craniorachischisis
- decreased body size
- dilated brain ventricles
- disorganized retinal layers
- domed cranium
- ductus venosus stenosis
- embryonic lethality complete penetrance
- enlarged brain ventricles
- exencephaly
- hemorrhage
- hydrocephaly
- increased T cell derived lymphoma incidence
- increased embryonic neuroepithelial cell proliferation
- increased hemangiosarcoma incidence
- increased incidence of tumors by ionizing radiation induction
- increased lymphoma incidence
- increased neuron apoptosis
- increased neuronal precursor cell number
- increased rhabdomyosarcoma incidence
- increased squamous cell carcinoma incidence
- increased tumor incidence
- intracranial hemorrhage
- intraventricular hemorrhage
- micrognathia
- microphthalmia
- narrow head
- neonatal lethality complete penetrance
- perinatal lethality incomplete penetrance
- postnatal lethality complete penetrance
- small thymus
- spina bifida
- umbilical vein stenosis
- ventricular septal defect
- wavy neural tube
role in cell
- growth
- proliferation
- expression in
- activation in
- cell death
- apoptosis
- phosphorylation in
- binding in
- transmembrane potential
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell junction
- Cytoplasm
- perinuclear region
- vesicles
- cytosol
- nucleoplasm
- perinuclear vesicles
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trp53bp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- signal transduction by p53 class mediator resulting in induction of apoptosis
- negative regulation of cell cycle
- positive regulation of execution phase of apoptosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- cell junction
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- NF-kappaB binding
- p53 binding
- identical protein binding
- protein binding
- protein homodimerization activity
- SH3 domain binding