Orc1 Gene Summary [Mouse]
Predicted to enable DNA replication origin binding activity and chromatin binding activity. Predicted to be involved in DNA replication initiation; positive regulation of smooth muscle cell proliferation; and regulation of cell cycle process. Predicted to act upstream of or within DNA replication. Predicted to be located in nucleoplasm. Predicted to be part of nuclear origin of replication recognition complex. Predicted to colocalize with chromosome, telomeric region. Is expressed in liver and submandibular gland. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 1. Orthologous to human ORC1 (origin recognition complex subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Orc1 |
| Official Name | origin recognition complex, subunit 1 [Source:MGI Symbol;Acc:MGI:1328337] |
| Ensembl ID | ENSMUSG00000028587 |
| Bio databases IDs | |
| Aliases | origin recognition complex, subunit 1 |
| Synonyms | HSORC1, MmORC1, ORC1L, Origin recognition, origin recognition complex subunit 1, origin recognition complex, subunit 1, PARC1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Orc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BAH domain
- BAH
- ATPase family associated with various cellular activities (AAA)
- orc1/cdc6 family replication initiation protein
- AAA+ domain
- chromatin binding
- protein binding
- Cdc6 winged-helix domain
- CDC6, C terminal winged helix domain
- DNA binding
Pathways
Biological processes and signaling networks where the Orc1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma formation
- epithelial neoplasia
- neoplasia
- liver neoplasia
- organismal death
- Meier-Gorlin syndrome type 1
- lung adenocarcinoma
- breast carcinoma
- ovarian granulosa cell tumor
- ovarian neoplasia
role in cell
- proliferation
- cell death
- loss in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- chromatin fraction
- nuclear matrix fraction
- heterochromatic focus
- telomeric heterochromatin
- Cytoplasm
- nucleolar region
- perinuclear region
- cytosol
- nuclear foci
- perinucleolar compartments
- nucleoplasm
- nuclear rim
- nuclear matrix
- telomeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Orc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA-dependent DNA replication initiation
- mitotic cell cycle DNA replication checkpoint
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- origin recognition complex
- cytosol
- nuclear origin of replication recognition complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- DNA binding
- ATP binding
- DNA replication origin binding
- protein binding
- metal ion binding
- chromatin binding