NMI Gene Summary [Human]
NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NMI |
| Official Name | N-myc and STAT interactor [Source:HGNC Symbol;Acc:HGNC:7854] |
| Ensembl ID | ENSG00000123609 |
| Bio databases IDs | |
| Aliases | N-myc and STAT interactor |
| Synonyms | N-myc (and STAT) interactor, N-myc and STAT interactor, N-MYC INTERACTOR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NMI often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- transcription regulator
- Nmi/IFP35 domain
- protein binding
- Interferon-induced 35 kDa protein (IFP 35) N-terminus
- identical protein binding
- Nmi/IFP 35 domain (NID)
Pathways
Biological processes and signaling networks where the NMI gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- COVID-19
- spinal cord demyelination
- insulitis
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- neonatal late-onset sepsis
- Hutchinson-Gilford progeria syndrome
- psoriasis
role in cell
- binding in
- expression in
- apoptosis
- proliferation
- activation
- interaction in
- replication in
- activation in
- cellular infiltration
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- cellular membrane
- Nucleus
- granules
- cytosol
- nuclear foci
- nucleoplasm
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NMI gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K48-linked ubiquitination
- negative regulation of cell proliferation
- toll-like receptor 4 signaling pathway
- positive regulation of inflammatory response
- macrophage activation involved in immune response
- response to virus
- negative regulation of innate immune response
- JAK-STAT cascade
- positive regulation of innate immune response
- innate immune response
- negative regulation of interferon-alpha production
- negative regulation of interferon-beta production
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- cytoplasm
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding