NCKAP1 Gene Summary [Human]
Contributes to small GTPase binding activity. Involved in Rac protein signal transduction; positive regulation of Arp2/3 complex-mediated actin nucleation; and positive regulation of lamellipodium assembly. Located in extracellular exosome and focal adhesion. Part of SCAR complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NCKAP1 |
| Official Name | NCK associated protein 1 [Source:HGNC Symbol;Acc:HGNC:7666] |
| Ensembl ID | ENSG00000061676 |
| Bio databases IDs | |
| Aliases | NCK associated protein 1 |
| Synonyms | H19, HEM2, mh19, mKIAA0587, NAP1, NAP125, NCK-associated protein 1, p125Nap1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NCKAP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nck-associated protein 1
- Nap1-binding site
- cytoplasmic domain
- enzyme binding
- protein binding
Pathways
Biological processes and signaling networks where the NCKAP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- prostate cancer
- lung squamous cell carcinoma
- gastric cancer
- squamous cell lung cancer
- metastasis
- COVID-19
- breast cancer
- bladder cancer
- endometrioid cancer
role in cell
- apoptosis
- migration
- invasion by
- binding in
- differentiation
- polymerization
- invasiveness
- assembly
- polarization
- nucleation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- ruffle
- Cytoplasm
- postsynaptic region
- cellular membrane
- actin filaments
- cytosol
- growth cone
- synaptosomes
- cell membrane leading edge
- axons
- dendrites
- postsynaptic density
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NCKAP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of lamellipodium assembly
- Rac protein signal transduction
- cortical actin cytoskeleton organization
- central nervous system development
- cell projection assembly
- cell morphogenesis
- positive regulation of actin filament polymerization
- apoptotic process
- neuron projection morphogenesis
- positive regulation of Arp2/3 complex-mediated actin nucleation
- cell migration
Cellular Component
Where in the cell the gene product is active
- SCAR complex
- extracellular vesicular exosome
- focal adhesion
- ruffle
- cytosol
- filamentous actin
- lamellipodium
- lamellipodium membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding