Wasf3 Gene Summary [Mouse]
Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Involved in modification of postsynaptic actin cytoskeleton. Acts upstream of or within lamellipodium assembly; oligodendrocyte development; and positive regulation of myelination. Located in glial cell projection and lamellipodium. Is active in glutamatergic synapse and postsynapse. Is expressed in adrenal gland; cap mesenchyme; nervous system; and neural retina. Orthologous to human WASF3 (WASP family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wasf3 |
| Official Name | WASP family, member 3 [Source:MGI Symbol;Acc:MGI:2658986] |
| Ensembl ID | ENSMUSG00000029636 |
| Bio databases IDs | |
| Aliases | WASP family, member 3 |
| Synonyms | Brush-1, SCAR3, WASP family member 3, WASP family, member 3, WAVE3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wasf3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wiskott Aldrich syndrome homology region 2
- WA domain
- WH2
- protein binding
- WH2 motif
- Scar/WAVE homology domain
Pathways
Biological processes and signaling networks where the Wasf3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
regulates
- ARP2/3
- CDH1
- protein-protein complex
role in cell
- expression in
- migration
- polarization
- formation
- invasion
- expansion
- expansion in
- organization
- assembly
- polymerization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- perinuclear region
- postsynaptic region
- glial cell projections
- exosomes
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wasf3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- oligodendrocyte development
- cytoskeleton organization
- macromolecular complex assembly
- actin filament polymerization
- lamellipodium assembly
- positive regulation of Arp2/3 complex-mediated actin nucleation
- actin cytoskeleton organization
- positive regulation of myelination
Cellular Component
Where in the cell the gene product is active
- SCAR complex
- extracellular vesicular exosome
- cytoskeleton
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- actin binding
- protein kinase A regulatory subunit binding
- Arp2/3 complex binding