Ehf Gene Summary [Mouse]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in epithelial cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; female reproductive system; gut; nose; and urinary system. Orthologous to human EHF (ETS homologous factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ehf |
| Official Name | ets homologous factor [Source:MGI Symbol;Acc:MGI:1270840] |
| Ensembl ID | ENSMUSG00000012350 |
| Bio databases IDs | |
| Aliases | ets homologous factor |
| Synonyms | 9030625L19Rik, ESE3, ESEJ, ETS homologous factor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ehf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Sterile alpha motif (SAM)/Pointed domain
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- SAM (Sterile alpha motif )
- Ets-domain
- protein binding
- sequence-specific DNA binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- renal clear cell adenocarcinoma
- renal clear cell cancer
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- COVID-19
- organismal death
role in cell
- proliferation
- expression in
- apoptosis
- production in
- cell cycle progression
- activation in
- growth
- colony formation
- migration
- wound closure
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Golgi Apparatus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ehf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- Golgi apparatus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity