Myef2 Gene Summary [Mouse]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; liver; sensory organ; thymus; and vertebral axis musculature. Orthologous to human MYEF2 (myelin expression factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Myef2 |
| Official Name | myelin basic protein expression factor 2, repressor [Source:MGI Symbol;Acc:MGI:104592] |
| Ensembl ID | ENSMUSG00000027201 |
| Bio databases IDs | |
| Aliases | myelin basic protein expression factor 2, repressor |
| Synonyms | 9430071B01, HsT18564, MEF-2, mKIAA1341, MST156, MSTP156, myelin basic protein expression factor 2, repressor, myelin expression factor 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myef2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- transcription regulator
- MARF1, RNA recognition motif 1
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- nucleic acid binding
- RNA recognition motif
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- oculocutaneous albinism type VI
- Huntington disease
- acute myeloid leukemia
- oculocutaneous albinism
- colon cancer
- hereditary disorder
- small cell lung cancer
- infection by HIV-1
regulates
- DNA promoter
- RNA polymerase II
- DNA endogenous promoter
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myef2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron differentiation
- myotube differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA binding
- mRNA binding