Arhgap1 Gene Summary [Mouse]
Enables GTPase activator activity. Predicted to be involved in several processes, including negative regulation of endocytic recycling; small GTPase-mediated signal transduction; and transferrin transport. Located in plasma membrane and ruffle. Is expressed in cerebral cortex subventricular zone; cerebral cortex ventricular layer; and cortical plate. Orthologous to human ARHGAP1 (Rho GTPase activating protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgap1 |
| Official Name | Rho GTPase activating protein 1 [Source:MGI Symbol;Acc:MGI:2445003] |
| Ensembl ID | ENSMUSG00000027247 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 1 |
| Synonyms | B230365D05RIK, C76222, CDC42GAP, CDC42 GTPase-ACTIVATING, p50rhoGAP, RHOGAP, RHOGAP1, Rho GTPase activating protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- Domain in homologues of a S
- BCH domain
- Divergent CRAL/TRIO domain
- catalytic domain
- enzyme binding
- CRAL/TRIO domain
- GTPase activator
- protein binding
- GTPase Activating Protein domain
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
Pathways
Biological processes and signaling networks where the Arhgap1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- kyphosis
- lordokyphosis
- hypertrophic cardiomyopathy
- open-angle glaucoma
- schizophrenia
- diverticular disease
- non-insulin-dependent diabetes mellitus
- hypoplasia
- growth failure
- premature aging
role in cell
- quantity
- proliferation
- apoptosis
- migration
- formation
- abnormal morphology
- motility
- generation
- doubling time
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- ruffle
- cilia
- perinuclear region
- Nucleus
- Plasma Membrane
- cytosol
- endosomal membrane
- cell membrane leading edge
- sorting endosomes
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
- transferrin transport
- small GTPase mediated signal transduction
- endosomal transport
- Rho protein signal transduction
- negative regulation of endocytic recycling
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- endosome membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding
- GTPase activator activity
- small GTPase binding
- SH3 domain binding