Bpifa1 Gene Summary [Mouse]
Predicted to enable lipid binding activity. Involved in antibacterial humoral response; innate immune response; and negative regulation of single-species biofilm formation in or on host organism. Predicted to be located in extracellular region and microvillus. Predicted to be active in extracellular space. Is expressed in hemolymphoid system; nose; respiratory system; and turbinate bone. Used to study otitis media. Orthologous to human BPIFA1 (BPI fold containing family A member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bpifa1 |
| Official Name | BPI fold containing family A, member 1 [Source:MGI Symbol;Acc:MGI:1338036] |
| Ensembl ID | ENSMUSG00000027483 |
| Bio databases IDs | |
| Aliases | BPI fold containing family A, member 1 |
| Synonyms | bA49G10.5, BPI fold containing family A member 1, BPI fold containing family A, member 1, LUNX, NASG, PLUNC, SPLUNC1, SPURT |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bpifa1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- BPI
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pneumonia
- non-small cell lung carcinoma
- non-small cell lung cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- primary pulmonary hypertension
- infection by Pseudomonas aeruginosa
role in cell
- expression in
- apoptosis
- phosphorylation in
- formation in
- growth
- proliferation
- cellular infiltration by
- clearance
- migration
- M1 polarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bpifa1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organismal water homeostasis
- innate immune response
- defense response to virus
- antibacterial humoral response
- immune response in nasopharyngeal-associated lymphoid tissue
- negative regulation of single-species biofilm formation in or on host organism
- surfactant homeostasis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- lipid binding