Dnase2b Gene Summary [Mouse]
Enables DNA endonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Located in cytoplasm and extracellular region. Is expressed in ganglia; medulla oblongata basal plate mantle layer; and ventral grey horn. Used to study cataract. Orthologous to human DNASE2B (deoxyribonuclease 2 beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnase2b |
| Official Name | deoxyribonuclease II beta [Source:MGI Symbol;Acc:MGI:1913283] |
| Ensembl ID | ENSMUSG00000028185 |
| Bio databases IDs | |
| Aliases | deoxyribonuclease II beta |
| Synonyms | deoxyribonuclease 2 beta, deoxyribonuclease 2 β, deoxyribonuclease II beta, deoxyribonuclease II β, DLAD, DnaseIIb, UOX |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnase2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endonuclease
- enzyme
- deoxyribonuclease II
- Catalytic domain of phospholipase D superfamily proteins
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- lysosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dnase2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic DNA fragmentation
Cellular Component
Where in the cell the gene product is active
- extracellular region
- lysosome
Molecular Function
What the gene product does at the molecular level
- deoxyribonuclease II activity