Col15a1 Gene Summary [Mouse]
Predicted to be an extracellular matrix structural constituent conferring tensile strength. Predicted to be involved in extracellular matrix organization. Located in basement membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart and pericardium; metatarsal bone; and nervous system. Orthologous to human COL15A1 (collagen type XV alpha 1 chain). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Col15a1 |
| Official Name | collagen, type XV, alpha 1 [Source:MGI Symbol;Acc:MGI:88449] |
| Ensembl ID | ENSMUSG00000028339 |
| Bio databases IDs | |
| Aliases | collagen, type XV, alpha 1 |
| Synonyms | Col15, COL15A, collagen, type XV, alpha 1, collagen type XV alpha 1 chain, collagen, type XV, α 1, collagen type XV α 1 chain, Collagen xv, LOC108348074 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Col15a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular matrix structural constituent conferring tensile strength
- Concanavalin A-like lectin/glucanases superfamily
- Collagen trimerization domain
- LamG
- Endostatin-like
- Collagenase NC10 and Endostatin
- Collagen triple helix repeat (20 copies)
- protein binding
- endostatin domain
Pathways
Biological processes and signaling networks where the Col15a1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- angioimmunoblastic T-cell lymphoma
- squamous cell cancer of the oral cavity
- hepatocellular carcinoma
- oral squamous cell carcinoma
- ovarian carcinoma
- epithelial cancer
- serous ovarian adenocarcinoma
- epithelial ovarian cancer
- colorectal cancer
role in cell
- morphology
- degeneration
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
- extracellular matrix
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Col15a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- angiogenesis
- extracellular matrix organization
- cell differentiation
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- basement membrane
- extracellular vesicular exosome
- membrane
- collagen type XV
- extracellular region
Molecular Function
What the gene product does at the molecular level
- extracellular matrix structural constituent conferring tensile strength