Nudt2 Gene Summary [Mouse]
Predicted to enable bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity. Predicted to be involved in AMP biosynthetic process; ATP biosynthetic process; and apoptotic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Orthologous to human NUDT2 (nudix hydrolase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nudt2 |
| Official Name | nudix (nucleoside diphosphate linked moiety X)-type motif 2 [Source:MGI Symbol;Acc:MGI:1913651] |
| Ensembl ID | ENSMUSG00000028443 |
| Bio databases IDs | |
| Aliases | nudix (nucleoside diphosphate linked moiety X)-type motif 2 |
| Synonyms | 2310051L06Rik, Ap4A hydrolase, APAH1, IDDPN, nudix hydrolase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nudt2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NUDIX domain
- phosphatase
- Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)
- protein binding
- hydrolase
- Bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
- NUDIX hydrolase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- intellectual developmental disorder with or without peripheral neuropathy
- intellectual developmental disorder without peripheral neuropathy
- mental retardation
- intellectual developmental disorder with peripheral neuropathy
- complex neurodevelopmental disorder
role in cell
- activation in
- accumulation in
- apoptosis
- expression in
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent resistant lipid raft fraction
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nudt2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process
- AMP biosynthetic process
- cellular response to oxidative stress
- ATP biosynthetic process
- nucleobase-containing compound metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
Molecular Function
What the gene product does at the molecular level
- GTP binding
- bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
- bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity
- protein binding