Ndrg4 Gene Summary [Mouse]
Involved in several processes, including regulation of endocytic recycling; vesicle docking; and visual learning. Located in cell projection membrane and cytoplasm. Is expressed in several structures, including genitourinary system; gut; nervous system; respiratory system; and retina. Orthologous to human NDRG4 (NDRG family member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndrg4 |
| Official Name | N-myc downstream regulated gene 4 [Source:MGI Symbol;Acc:MGI:2384590] |
| Ensembl ID | ENSMUSG00000036564 |
| Bio databases IDs | |
| Aliases | N-myc downstream regulated gene 4 |
| Synonyms | AF045564, BDM1, D8Bwg1337e, Ndr1-rs, NDR4, NDRG family member 4, N-myc downstream regulated gene 4, SMAP-8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ndrg4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha/beta hydrolases
- Ndr family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- benign neoplasia
- adenoma formation
- lung adenocarcinoma formation
- idiopathic pulmonary fibrosis
- schizophrenia
- colon cancer
- ischemic injury
- lung adenocarcinoma
role in cell
- migration
- expression in
- proliferation
- development
- docking
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cytosol
- endoplasmic reticulum membrane
- basolateral membrane
- cellular protrusions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ndrg4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- visual learning
- embryonic heart tube development
- cell migration involved in heart development
- cardiac muscle cell proliferation
- vesicle docking
- negative regulation of smooth muscle cell proliferation
- positive regulation of ERK1 and ERK2 cascade
- cell differentiation
- heart looping
- positive regulation of neuron projection development
- negative regulation of smooth muscle cell migration
- regulation of endocytic recycling
- negative regulation of platelet-derived growth factor receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- mitochondrion
- cytosol
- cell projection membrane
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding