Myl4 Gene Summary [Mouse]
Predicted to enable actin filament binding activity and actin monomer binding activity. Predicted to be involved in cardiac muscle contraction; positive regulation of ATP-dependent activity; and regulation of the force of heart contraction. Predicted to be part of myosin II complex. Predicted to be active in A band. Is expressed in several structures, including alimentary system; brain; great vessel of heart; heart; and limb. Human ortholog(s) of this gene implicated in cardiomyopathy and familial atrial fibrillation. Orthologous to human MYL4 (myosin light chain 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myl4 |
| Official Name | myosin, light polypeptide 4 [Source:MGI Symbol;Acc:MGI:97267] |
| Ensembl ID | ENSMUSG00000061086 |
| Bio databases IDs | |
| Aliases | myosin, light polypeptide 4 |
| Synonyms | ALC1, AMLC, ELC, Elc1a, GT1, Malc, MLC1, MLC-1a, MLC1EMB, MLC2A, Myla, myosin light chain 4, myosin, light chain 4, myosin, light polypeptide 4, PRO1957 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myl4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- actin monomer binding
- EFh
Pathways
Biological processes and signaling networks where the Myl4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Agranulocyte Adhesion and Diapedesis
- Apelin Cardiomyocyte Signaling Pathway
- Calcium Signaling
- Cardiac Hypertrophy Signaling
- Cdc42 Signaling
- Cellular Effects of Sildenafil (Viagra)
- CXCR4 Signaling
- Ephrin A Signaling
- Estrogen Receptor Signaling
- G-Protein Coupled Receptor Signaling
- Gα12/13 Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- ILK Signaling
- PAK Signaling
- Phagosome Formation
- Regulation of Actin-based Motility by Rho
- RhoA Signaling
- RhoGDI Signaling
- Signaling by Rho Family GTPases
- Thrombin Signaling
- Tight Junction Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- sarcomere
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myl4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of the force of heart contraction
- positive regulation of ATPase activity
- cardiac muscle contraction
Cellular Component
Where in the cell the gene product is active
- myosin II complex
- cytosol
- A band
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- calcium ion binding
- myosin II heavy chain binding
- actin monomer binding