Gale Gene Summary [Mouse]
Enables UDP-glucose 4-epimerase activity. Involved in galactose catabolic process via UDP-galactose, Leloir pathway. Acts upstream of or within galactose metabolic process. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in galactose epimerase deficiency and thrombocytopenia. Orthologous to human GALE (UDP-galactose-4-epimerase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gale |
| Official Name | galactose-4-epimerase, UDP [Source:MGI Symbol;Acc:MGI:1921496] |
| Ensembl ID | ENSMUSG00000028671 |
| Bio databases IDs | |
| Aliases | galactose-4-epimerase, UDP |
| Synonyms | 2310002A12Rik, galactose-4-epimerase, UDP, Galactowaldenase, SDR1E1, THC13, UDP-galactose-4-epimerase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gale often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- Male sterility protein
- NAD dependent epimerase/dehydratase family
- enzyme
- UDP-N-acetylglucosamine 4-epimerase
- UDPglucose 4-epimerase
- identical protein binding
- NmrA-like family
- 3-beta hydroxysteroid dehydrogenase/isomerase family
- UDP-glucose-4-epimerase GalE
- protein homodimerization
- short chain dehydrogenase
- GDP-mannose 4,6 dehydratase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- udpglucose-4-epimerase deficiency
- syndromic thrombocytopenia type 13
- hereditary disorder
- macrothrombocytopenia
- epithelial thyroid cancer
- thyroid carcinoma
- papillary thyroid carcinoma
- papillary thyroid cancer
- uterine serous papillary cancer
role in cell
- apoptosis
- glycosylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gale gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- galactose catabolic process
- galactose catabolic process via UDP-galactose
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- UDP-N-acetylglucosamine 4-epimerase activity
- identical protein binding
- protein homodimerization activity
- UDP-glucose 4-epimerase activity