Arhgef19 Gene Summary [Mouse]
Predicted to enable GTPase activator activity and guanyl-nucleotide exchange factor activity. Acts upstream of or within positive regulation of GTPase activity and wound healing. Is expressed in several structures, including genitourinary system; nose; oral epithelium; pharyngo-tympanic tube; and skin. Orthologous to human ARHGEF19 (Rho guanine nucleotide exchange factor 19). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgef19 |
| Official Name | Rho guanine nucleotide exchange factor (GEF) 19 [Source:MGI Symbol;Acc:MGI:1925912] |
| Ensembl ID | ENSMUSG00000028919 |
| Bio databases IDs | |
| Aliases | Rho guanine nucleotide exchange factor (GEF) 19 |
| Synonyms | 6030432F23, 6430573B13Rik, DKFZP586P2321, Rho guanine nucleotide exchange factor 19, WGEF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgef19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGEF
- guanyl-nucleotide exchange factor
- PH domain
- protein binding
- Pleckstrin homology-like domain
- zDHHC ankyrin repeat binding domain
- RhoGEF domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Arhgef19 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgef19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- wound healing
- regulation of actin cytoskeleton organization
- regulation of small GTPase mediated signal transduction
- Wnt receptor signaling pathway, planar cell polarity pathway
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity
- guanyl-nucleotide exchange factor activity