Card6 Gene Summary [Mouse]
Predicted to act upstream of or within regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytoplasm. Is expressed in heart ventricle; lung; upper arm muscle; upper leg muscle; and vertebral axis musculature. Orthologous to human CARD6 (caspase recruitment domain family member 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Card6 |
| Official Name | caspase recruitment domain family, member 6 [Source:MGI Symbol;Acc:MGI:3032959] |
| Ensembl ID | ENSMUSG00000041849 |
| Bio databases IDs | |
| Aliases | caspase recruitment domain family, member 6 |
| Synonyms | caspase recruitment domain family member 6, caspase recruitment domain family, member 6, CINCIN1, D730008L15 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Card6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- core domain, structural
- Caspase recruitment domain
- protein binding
- glutamic acid-rich domain
- Death Domain Superfamily of protein-protein interaction domains
- proline rich domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiac hypertrophy
- interstitial fibrosis
- perivascular fibrosis
- multiple system atrophy
- left ventricular dysfunction
regulates
- NFkB (complex)
- ERK1/2
- MAP2K1
- MAP2K1/2
- JINK1/2
role in cell
- hypertrophy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Card6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process
- regulation of apoptotic process
Molecular Function
What the gene product does at the molecular level
- protein binding