Nelfa Gene Summary [Mouse]
Enables chromatin binding activity. Acts upstream of or within negative regulation of transcription elongation by RNA polymerase II. Located in nucleus. Is expressed in several structures, including blastocyst; early embryo; genitourinary system; liver; and spleen. Orthologous to human NELFA (negative elongation factor complex member A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nelfa |
| Official Name | negative elongation factor complex member A, Whsc2 [Source:MGI Symbol;Acc:MGI:1346098] |
| Ensembl ID | ENSMUSG00000029111 |
| Bio databases IDs | |
| Aliases | negative elongation factor complex member A, Whsc2 |
| Synonyms | LOC107986248, negative elongation factor complex member A, negative elongation factor complex member A, Whsc2, P/OKcl.15, WHSC2, WHSC2H |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nelfa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- aortic valve calcification
- breast carcinoma
- Alzheimer disease
role in cell
- transcription in
- expression in
- proliferation
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nelfa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription elongation from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of protein modification process
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- NELF complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- chromatin binding
- binding, bridging