Ccne2 Gene Summary [Mouse]
Enables cyclin-dependent protein serine/threonine kinase regulator activity. Acts upstream of or within several processes, including DNA replication initiation; chromosome organization; and regulation of protein localization. Part of cyclin E2-CDK2 complex. Is expressed in several structures, including genitourinary system; heart; mammary gland; and telencephalon. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma. Orthologous to human CCNE2 (cyclin E2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Ccne2 |
| Official Name | cyclin E2 [Source:MGI Symbol;Acc:MGI:1329034] |
| Ensembl ID | ENSMUSG00000028212 |
| Bio databases IDs | |
| Aliases | cyclin E2 |
| Synonyms | AV063769, CYCE2, cyclin E2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccne2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- Cyclin box fold superfamily
- Cyclin, N-terminal domain
- protein binding
- domain present in cyclins, TFIIB and Retinoblastoma
- cyclin-dependent protein kinase regulator
Pathways
Biological processes and signaling networks where the Ccne2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Antiproliferative Role of TOB in T Cell Signaling
- Aryl Hydrocarbon Receptor Signaling
- Cell Cycle Regulation by BTG Family Proteins
- Cyclins and Cell Cycle Regulation
- DNA damage-induced 14-3-3σ Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Estrogen-mediated S-phase Entry
- GADD45 Signaling
- Glioblastoma Multiforme Signaling
- HER-2 Signaling in Breast Cancer
- Molecular Mechanisms of Cancer
- Pancreatic Adenocarcinoma Signaling
- Prostate Cancer Signaling
- Regulation of Cellular Mechanics by Calpain Protease
- Serotonin Receptor Signaling
- Small Cell Lung Cancer Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck squamous cell cancer
- neoplasia
- non-small cell lung cancer
- lung adenocarcinoma
- invasive breast cancer
- squamous cell lung cancer
- lung squamous cell carcinoma
- mammary neoplasm
- transitional cell bladder cancer
- invasive breast carcinoma
role in cell
- proliferation
- expression in
- G1/S phase transition
- transformation
- cell cycle progression
- endoreduplication
- CSN5i-3 sensitivity
- meiosis
- abnormality
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- ribosome
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccne2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- DNA-dependent DNA replication initiation
- positive regulation of G1/S transition of mitotic cell cycle
- regulation of protein localization
- G1/S transition of mitotic cell cycle
- telomere maintenance
- synapsis
- regulation of cyclin-dependent protein kinase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cyclin E2-CDK2 complex
- cyclin E1-CDK2 complex
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- cyclin-dependent protein kinase regulator activity