Pgm2 Gene Summary [Mouse]
Enables phosphoglucomutase activity. Involved in glycogen biosynthetic process and glycogen catabolic process. Acts upstream of or within glucose metabolic process. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; liver; oocyte; respiratory system; and telencephalon. Orthologous to human PGM2 (phosphoglucomutase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pgm2 |
| Official Name | phosphoglucomutase 2 [Source:MGI Symbol;Acc:MGI:97564] |
| Ensembl ID | ENSMUSG00000029171 |
| Bio databases IDs | |
| Aliases | phosphoglucomutase 2 |
| Synonyms | 3230402E02Rik, MSTP006, Pgm-1, Phosphoglucomutase, phosphoglucomutase 2, Phosphopentomutase, PPM |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pgm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphohexomutase
- phosphopentomutase
- phosphoglucosamine mutase
- Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
- enzyme
- protein binding
- phosphoglucomutase
- Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
- Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- anaplastic thyroid cancer
- anaplastic thyroid carcinoma
- epithelial thyroid cancer
- papillary thyroid carcinoma
- papillary thyroid cancer
- preeclampsia
- septic shock
- schizophrenia
regulates
- D-glucose
- glycogen
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pgm2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycogen biosynthetic process
- purine ribonucleoside salvage
- glycogen catabolic process
- glucose metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
- secretory granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- phosphoglucomutase activity
- protein binding
- phosphopentomutase activity