Gars Gene Summary [Mouse]
Enables glycine-tRNA ligase activity. Acts upstream of or within glycyl-tRNA aminoacylation. Located in extracellular exosome and secretory granule. Is expressed in several structures, including alimentary system; cardiovascular system; nervous system; respiratory system; and urinary system. Used to study Charcot-Marie-Tooth disease type 2D. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2D and autosomal dominant distal hereditary motor neuronopathy 5. Orthologous to human GARS1 (glycyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gars |
| Official Name | glycyl-tRNA synthetase [Source:MGI Symbol;Acc:MGI:2449057] |
| Ensembl ID | ENSMUSG00000029777 |
| Bio databases IDs | |
| Aliases | glycyl-tRNA synthetase |
| Synonyms | CMT2D, DSMAV, GARS, Gena201, GENA202, Glycine--tRNA ligase, glycyl-tRNA synthetase 1, GlyRS, GRS, HMN5, HMN5A, HMND5, Nmf249, RGD1559871, SGRP23, SMAD1, SMAJI |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gars often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein dimerization
- glycyl-tRNA synthetase, dimeric type
- HGTP_anticodon
- class_II_aaRS-like_core
- Anticodon binding domain
- glycine-tRNA ligase
- S15_NS1_EPRS_RNA-bind
- Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)
- WHEP-TRS
- enzyme
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- epithelial cancer
- renal cell cancer
- pancreatic adenocarcinoma
- pancreatic epithelial cancer
- cholangiocarcinoma cancer
- cervical cancer
- distal hereditary motor neuronopathy type 5
- Charcot-Marie-Tooth disease type 2
- muscle weakness
role in cell
- phosphorylation in
- binding in
- neurite outgrowth in
- translation in
- pausing in
- pausing
- integrated stress response in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
- secretory granules
- axons
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gars gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA aminoacylation for protein translation
- mitochondrial glycyl-tRNA aminoacylation
- diadenosine tetraphosphate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- mitochondrial matrix
- cytoplasm
- secretory granule
- mitochondrion
- cytosol
- axon
Molecular Function
What the gene product does at the molecular level
- glycine-tRNA ligase activity
- ATP binding
- identical protein binding
- bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
- protein binding
- protein dimerization activity
- transferase activity