Nt5c3 Gene Summary [Mouse]
Enables 5'-nucleotidase activity. Involved in CMP catabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; hemolymphoid system; liver; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia 8. Orthologous to human NT5C3A (5'-nucleotidase, cytosolic IIIA). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nt5c3 |
| Official Name | 5'-nucleotidase, cytosolic III [Source:MGI Symbol;Acc:MGI:1927186] |
| Ensembl ID | ENSMUSG00000029780 |
| Bio databases IDs | |
| Aliases | 5'-nucleotidase, cytosolic III |
| Synonyms | 1600024P05Rik, 2610206B05Rik, 3110004A18RIK, 5'-nucleotidase, cytosolic III, 5'-nucleotidase, cytosolic IIIA, cN-III, CNSHA8, hUMP1, lupin, NT5C3, Nt5y, p36, P5'N-1, P5N-1, PN-1, PN-I, POMP, PSN1, UMPH, UMPH1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nt5c3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- haloacid dehalogenase superfamily, subfamily IE hydrolase, TIGR01544
- tRNA 2'-phosphotransferase
- 5'-nucleotidase
- Pyrimidine 5'-nucleotidase (UMPH-1)
- Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like
- phosphatase
- protein binding
- Haloacid Dehalogenase-like Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- pyrimidine 5'-nucleotidase deficient hemolytic anemia
- early onset hypertension
regulates
- nicotinate D-ribonucleoside
- adenosine
- 5'-CMP
- nicotinate D-ribonucleotide
- NMN
role in cell
- proliferation
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nt5c3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- defense response to virus
- pyrimidine nucleoside metabolic process
- nucleotide metabolic process
Cellular Component
Where in the cell the gene product is active
- nuclear body
- cytoplasm
- cytosol
- endoplasmic reticulum
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- magnesium ion binding
- protein binding
- 5'-nucleotidase activity
- tRNA 2'-phosphotransferase activity