PCYOX1
PCYOX1 Gene Summary
Prenylcysteine is released during the degradation of prenylated proteins. PCYOX1 catalyzes the degradation of prenylcysteine to yield free cysteines and a hydrophobic isoprenoid product (Tschantz et al., 1999 [PubMed 10585463]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | PCYOX1 |
| Official Name | prenylcysteine oxidase 1 [Source:HGNC Symbol;Acc:HGNC:20588] |
| Ensembl ID | ENSG00000116005 |
| Bio databases IDs | |
| Aliases | prenylcysteine oxidase 1 |
| Synonyms | 1200015P13Rik,Clp55,KIAA0908,PCL1,Pcly,prenylcysteine oxidase 1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- FAD binding
- prenylcysteine lyase
- prenylcysteine oxidase
- NAD(P)-binding Rossmann-like domain
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the PCYOX1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- RHOBTB3
- ECPAS
- TRDN
- EMC4
- CANX
- SCARB2
- PINK1
- TNPO2
- STAT1
- TUBB8
disease
- anaplastic thyroid cancer
- anaplastic thyroid carcinoma
- COVID-19
- papillary thyroid carcinoma
- epithelial thyroid cancer
- papillary thyroid cancer
regulated by
- MAPT
- beta-estradiol
- CD28
- CD3 (complex)
- PPARD
- ESR1
- SMARCAL1
- phytohemagglutinin
- ESR2
- LYSET
regulates
- En2
- chloride
- L-cysteine
- geranylgeranylcysteine
- S-farnesylcysteine
role in cell
- contact growth inhibition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- lysosome
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PCYOX1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- prenylated protein catabolic process
- prenylcysteine catabolic process
CELLULAR COMPONENT
Where in the cell the gene product is active
- very-low-density lipoprotein particle
- extracellular vesicular exosome
- lysosome
MOLECULAR FUNCTION
What the gene product does at the molecular level
- FAD binding
- protein binding
- prenylcysteine oxidase activity