Adamts9 Gene Summary [Mouse]
Enables endopeptidase activity. Involved in several processes, including circulatory system development; negative regulation of endothelial cell migration; and negative regulation of sprouting angiogenesis. Acts upstream of or within several processes, including camera-type eye development; positive regulation of melanocyte differentiation; and response to bacterium. Located in cell surface and extracellular space. Is expressed in several structures, including alimentary system; embryo mesenchyme; endocrine gland; eye; and genitourinary system. Orthologous to human ADAMTS9 (ADAM metallopeptidase with thrombospondin type 1 motif 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adamts9 |
| Official Name | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9 [Source:MGI Symbol;Acc:MGI:1916320] |
| Ensembl ID | ENSMUSG00000030022 |
| Bio databases IDs | |
| Aliases | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9 |
| Synonyms | 1810011L16Rik, 8430403M15RIK, ADAM metallopeptidase with thrombospondin type 1 motif 9, ADAM metallopeptidase with thrombospondin type 1 motif, 9, ADAMTS9 isooform 3, E030027K14RIK, Gsfund3, Mhdaund3, Mhdaund4, UND3, UND4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adamts9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- Reprolysin family propeptide
- ADAMTS cysteine-rich domain 2
- ADAMTS cysteine-rich domain
- peptidase
- metallopeptidase
- ADAM-TS Spacer 1
- ZnMc
- endopeptidase
- Metallo-peptidase family M12B Reprolysin-like
- GON domain
- thrombospondin properdin-like repeat
- Reprolysin (M12B) family zinc metalloprotease
- Spondin-like TSP1 domain
Pathways
Biological processes and signaling networks where the Adamts9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- osteoarthritis
- gout
- colorectal cancer
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- microphthalmia
- non-insulin-dependent diabetes mellitus
- Dupuytren contracture
- diabetes mellitus
role in cell
- expression in
- quantity
- activation in
- differentiation
- morphology
- organization
- migration by
- tumorigenicity
- ciliogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular membrane-bounded organelle
- cell surface
- Endoplasmic Reticulum
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adamts9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- aorta morphogenesis
- melanocyte differentiation
- response to bacterium
- vesicle-mediated transport
- ventricular cardiac muscle tissue development
- proteolysis
- protein transport
- extracellular matrix organization
- positive regulation of melanocyte differentiation
- negative regulation of endothelial cell migration
- heart valve morphogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- intracellular membrane-bounded organelle
- endoplasmic reticulum
- extracellular matrix
- cell surface
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- metalloendopeptidase activity
- metallopeptidase activity