Klrg1 Gene Summary [Mouse]
Predicted to enable carbohydrate binding activity. Predicted to be involved in innate immune response. Predicted to act upstream of or within cell surface receptor signaling pathway. Predicted to be located in intracellular membrane-bounded organelle. Orthologous to human KLRG1 (killer cell lectin like receptor G1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klrg1 |
| Official Name | killer cell lectin-like receptor subfamily G, member 1 [Source:MGI Symbol;Acc:MGI:1355294] |
| Ensembl ID | ENSMUSG00000030114 |
| Bio databases IDs | |
| Aliases | killer cell lectin-like receptor subfamily G, member 1 |
| Synonyms | 2F1, 2F1-Ag, CLEC15A, killer cell lectin like receptor G1, killer cell lectin-like receptor subfamily G, member 1, Klrg, MAFA, MAFA-2F1, MAFA-L, MAFA-LIKE |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klrg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- immunoreceptor tyrosine-based inhibition motif
- Lectin C-type domain
- protein binding
- carbohydrate binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- ovarian cancer
- colon cancer
- sepsis
- organismal death
- insulin-dependent diabetes mellitus
- septic shock
- respiratory disorder
- Sjögren syndrome
role in cell
- proliferation
- expression in
- growth
- differentiation
- production in
- reactivity
- adhesion
- response
- proliferative capacity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cell surface
- cellular membrane
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Klrg1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular defense response
- inflammatory response
- innate immune response
- cell surface receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity
- carbohydrate binding