Rasal2 Gene Summary [Mouse]
Involved in several processes, including adipose tissue development; response to dietary excess; and response to glucose. Is expressed in central nervous system; dorsal root ganglion; nose; and turbinate bone primordium. Orthologous to human RASAL2 (RAS protein activator like 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rasal2 |
| Official Name | RAS protein activator like 2 [Source:MGI Symbol;Acc:MGI:2443881] |
| Ensembl ID | ENSMUSG00000070565 |
| Bio databases IDs | |
| Aliases | RAS protein activator like 2 |
| Synonyms | 6530401P13, A330066M24RIK, KIAA0501, LOC120093156, NGAP, RAS protein activator like 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rasal2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- Coiled-coil region of CCDC155 or KASH
- polo kinase kinase
- RNase Y N-terminal region
- Ezrin/radixin/moesin, alpha-helical domain
- UDM1_RNF168_RNF169-like
- Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins
- GTPase activator
- protein binding
- Pleckstrin homology-like domain
- Domain of unknown function (DUF3498)
- Ras GTPase Activating Domain
- GTPase-activator protein for Ras-like GTPases
- GTPase-activator protein for Ras-like GTPase
- Outer membrane protein (OmpH-like)
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- advanced cancer
- cancer
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- prostate cancer
- colorectal cancer
- androgenic alopecia
role in cell
- expression in
- phosphorylation in
- proliferation
- binding in
- cell viability
- degradation in
- migration
- invasion by
- ubiquitination in
- downregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rasal2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- response to glucose stimulus
- signal transduction
- gene expression
- response to dietary excess
- adipose tissue development
- regulation of protein activation cascade
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity