Pianp Gene Summary [Mouse]
Enables protein domain specific binding activity. Acts upstream of or within several processes, including brain development; glutamate secretion; and visual learning. Is active in presynapse. Is expressed in head. Used to study autism spectrum disorder. Orthologous to human PIANP (PILR alpha associated neural protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pianp |
| Official Name | PILR alpha associated neural protein [Source:MGI Symbol;Acc:MGI:2441908] |
| Ensembl ID | ENSMUSG00000030329 |
| Bio databases IDs | |
| Aliases | PILR alpha associated neural protein |
| Synonyms | AI255183, AU067746, C12orf53, C530028O21Rik, LEDA1, PANP, PILR alpha associated neural protein, PILR α associated neural protein, RGD1304952 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pianp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein domain specific binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- L-glutamic acid
phenotypes
- abnormal cerebral cortex morphology
- abnormal emotion/affect behavior
- abnormal excitatory postsynaptic currents
- abnormal glutamic acid level
- abnormal paired-pulse facilitation
- abnormal response to novel object
- abnormal response to social novelty
- decreased Purkinje cell number
- decreased dentate gyrus size
- decreased prepulse inhibition
- enhanced behavioral response to amphetamine
- enhanced coordination
- increased anxiety-related response
- increased coping response
- increased grip strength
- increased grooming behavior
- increased neuron apoptosis
- premature neuronal precursor differentiation
- social withdrawal
- thin cerebellar granule layer
- thin cerebellar molecular layer
role in cell
- apoptosis
- number
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- presynaptic regions
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pianp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of immune response
Cellular Component
Where in the cell the gene product is active
- membrane
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding