Pdcd5 Gene Summary [Mouse]
Predicted to enable acetyltransferase activator activity; beta-tubulin binding activity; and heparin binding activity. Predicted to be involved in several processes, including cellular response to transforming growth factor beta stimulus; negative regulation of chaperone-mediated protein folding; and regulation of mitochondrion organization. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human PDCD5 (programmed cell death 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdcd5 |
| Official Name | programmed cell death 5 [Source:MGI Symbol;Acc:MGI:1913538] |
| Ensembl ID | ENSMUSG00000030417 |
| Bio databases IDs | |
| Aliases | programmed cell death 5 |
| Synonyms | 2200003D22Rik, NEWGENE 1310561, programmed cell death 5, TFAR19 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pdcd5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- protein binding
- enzyme activator activity
- heparin binding
- Double-stranded DNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic pulmonary fibrosis
- systemic lupus erythematosus
- Alzheimer disease
- dilated cardiomyopathy
- metastasis
- cardiac hypertrophy
- heart failure
- renal cell carcinoma
- renal cell cancer
- fibrosis
role in cell
- apoptosis
- activation in
- binding in
- ubiquitination in
- interaction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cell periphery
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pdcd5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- cellular response to transforming growth factor beta stimulus
- negative regulation of cell proliferation
- positive regulation of gene expression
- positive regulation of apoptotic process
- apoptotic process
- positive regulation of release of cytochrome c from mitochondria
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- beta-tubulin binding
- acetyltransferase activator activity
- heparin binding