Uhrf2 Gene Summary [Mouse]
Enables histone binding activity. Predicted to be involved in several processes, including negative regulation of gene expression via chromosomal CpG island methylation; protein autoubiquitination; and regulation of cell cycle. Located in heterochromatin and nucleus. Is expressed in several structures, including central nervous system; ear; early conceptus; female reproductive system; and urinary system. Orthologous to human UHRF2 (ubiquitin like with PHD and ring finger domains 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Uhrf2 |
| Official Name | ubiquitin-like, containing PHD and RING finger domains 2 [Source:MGI Symbol;Acc:MGI:1923718] |
| Ensembl ID | ENSMUSG00000024817 |
| Bio databases IDs | |
| Aliases | ubiquitin-like, containing PHD and RING finger domains 2 |
| Synonyms | 2310065A22Rik, D130071B19Rik, DKFZp434B0920, NIRF, RNF107, TDRD23, ubiquitin-like, containing PHD and RING finger domains 2, ubiquitin like with PHD and ring finger domains 2, URF2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Uhrf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- PHD zinc finger
- SUMO transferase activity
- ubiquitin protein ligase activity
- protein binding activity, bridging
- transcription factor binding
- enzyme
- Tandem tudor domain within UHRF1
- Ring finger domain
- protein binding
- Ubiquitin family
- Ubl1_cv_Nsp3_N-like
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- SAD/SRA domain
- Ubiquitin homologues
- PHD finger superfamily
- Tudor domain superfamily
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- colorectal cancer
- periodontitis
- neoplasia
- organismal death
- metastasis
- nonalcoholic fatty liver disease
role in cell
- accumulation in
- expression in
- proliferation
- apoptosis
- cell death
- degradation in
- accumulation
- binding in
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- nucleoplasm
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Uhrf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein sumoylation
- cell differentiation
- hypermethylation of CpG island
- regulation of cell cycle
- protein autoubiquitination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- heterochromatin
- nucleus
- centromeric heterochromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- ubiquitin-protein ligase activity
- protein binding
- metal ion binding
- histone binding
- SUMO ligase activity