PSMC4 Gene Summary [Human]
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Details
| Type | Protein Coding |
| Official Symbol | PSMC4 |
| Official Name | proteasome 26S subunit, ATPase 4 [Source:HGNC Symbol;Acc:HGNC:9551] |
| Ensembl ID | ENSG00000013275 |
| Bio databases IDs | |
| Aliases | proteasome 26S subunit, ATPase 4, protease 26S subunit 6, Tat-binding protein 7, MB67 interacting protein |
| Synonyms | CIP21, MIP224, PROTEASOMAL ATPASE TAT-binding protein 7, proteasome 26S subunit, ATPase 4, proteasome (prosome, macropain) 26S subunit, ATPase, 4, PRS6B, RPT3, S6, S6B, TBP-7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PSMC4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 26S proteasome subunit P45 family
- Proteasomal ATPase OB C-terminal domain
- walker type B motif
- peptidase
- walker type A motif
- leucine zipper domain
- protein binding
- AAA domain (Cdc48 subfamily)
- AAA+ lid domain
- ATPase
- helicase domain
- AAA domain (dynein-related subfamily)
- ATPase family associated with various cellular activities (AAA)
- HbYX motif
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- obesity
- astrocytosis
- microgliosis
- infection by HIV-1
role in cell
- cell viability
- cell death
- growth
- proliferation
- loss
- formation
- quantity
- degeneration
- accumulation in
- assembly in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- intracellular space
- basal bodies
- cytosol
- nucleoplasm
- synapse
- clastosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PSMC4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- blastocyst development
- proteolysis
Cellular Component
Where in the cell the gene product is active
- nucleus
- proteasome regulatory particle, base subcomplex
- membrane
- cytosol
- cytosolic proteasome complex
- proteasome complex
- proteasome accessory complex
- synapse
- inclusion body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding