PDE3B Gene Summary [Human]
Enables 3',5'-cyclic-nucleotide phosphodiesterase activity. Involved in negative regulation of angiogenesis; negative regulation of cell adhesion; and negative regulation of lipid catabolic process. Located in membrane. Part of guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PDE3B |
| Official Name | phosphodiesterase 3B [Source:HGNC Symbol;Acc:HGNC:8779] |
| Ensembl ID | ENSG00000152270 |
| Bio databases IDs | |
| Aliases | phosphodiesterase 3B |
| Synonyms | 3',5'-Cyclic phosphodiesterase B, 9830102A01RIK, cAMP-Dependent 3',5'-Cyclic Phosphodiesterase, CGI PDE, cGIPDE1, Cgmp-inhibited 3',5'-cyclic phosphodiesterase b, HcGIP1, LOC124902638, PDE3, Phosphodiesterase 3b, phosphodiesterase 3B, cGMP-inhibited, RcGIPl |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PDE3B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Metal dependent phosphohydrolases with conserved 'HD' motif
- 3'5'-cyclic nucleotide phosphodiesterase
- protein kinase binding
- 3',5'-cyclic-GMP phosphodiesterase
- cAMP-specific phosphodiesterase
- phosphoprotein binding
- enzyme
- protein binding
- HDc
- 3',5'-cyclic-nucleotide phosphodiesterase
Pathways
Biological processes and signaling networks where the PDE3B gene in human plays a role, providing insight into its function and relevance in health or disease.
- Apelin Pancreas Signaling Pathway
- cAMP-mediated signaling
- Cardiac β-adrenergic Signaling
- Cellular Effects of Sildenafil (Viagra)
- G-Protein Coupled Receptor Signaling
- Gustation Pathway
- Insulin Receptor Signaling
- Leptin Signaling in Obesity
- Nitric Oxide Signaling in the Cardiovascular System
- RAR Activation
- Relaxin Signaling
- TR/RXR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- rheumatoid arthritis
- Alzheimer disease
- obesity
- cardiovascular disorder
- metastasis
- heart disease
- hypertension
- renal failure
- chronic bronchitis
role in cell
- expression in
- lipolysis in
- proliferation
- migration
- formation
- morphology
- binding in
- adhesion
- size
- cell spreading
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- perinuclear region
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PDE3B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to insulin stimulus
- negative regulation of cell adhesion mediated by integrin
- negative regulation of angiogenesis
- G-protein coupled receptor signaling pathway
- angiogenesis
- negative regulation of cell adhesion
- cAMP-mediated signaling
- negative regulation of lipid catabolic process
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
- guanyl-nucleotide exchange factor complex
- Golgi apparatus
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
- protein binding
- metal ion binding
- protein kinase B binding
- 3',5'-cyclic-GMP phosphodiesterase activity
- 3',5'-cyclic-AMP phosphodiesterase activity
- 3',5'-cyclic-nucleotide phosphodiesterase activity