Cd37 Gene Summary [Mouse]
Acts upstream of or within several processes, including defense response to protozoan; negative regulation of leukocyte activation; and positive regulation of immunoglobulin production. Predicted to be located in immunological synapse. Predicted to be active in plasma membrane. Is expressed in thymus primordium. Orthologous to human CD37 (CD37 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd37 |
| Official Name | CD37 antigen [Source:MGI Symbol;Acc:MGI:88330] |
| Ensembl ID | ENSMUSG00000030798 |
| Bio databases IDs | |
| Aliases | CD37 antigen |
| Synonyms | CD37 antigen, CD37 molecule, GP52-40, TSPAN26 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd37 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tetraspanin_LEL
- protein binding
- Tetraspanin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- renal clear cell adenocarcinoma
- renal clear cell cancer
- laser induced choroidal neovascularization
- systemic lupus erythematosus
- interstitial cystitis/bladder pain syndrome
role in cell
- cell death
- proliferation
- activation in
- activation
- recruitment
- adhesion
- internalization by
- transendothelial migration
- chemotaxis
- cell division
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microvesicles
- cellular membrane
- immunological synapses
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd37 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- plasma membrane
- immunological synapse
Molecular Function
What the gene product does at the molecular level
- protein binding