Cd53 Gene Summary [Mouse]
Predicted to enable identical protein binding activity and protein-membrane adaptor activity. Involved in positive regulation of myoblast fusion. Located in cell-cell junction and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Orthologous to human CD53 (CD53 molecule). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd53 |
| Official Name | CD53 antigen [Source:MGI Symbol;Acc:MGI:88341] |
| Ensembl ID | ENSMUSG00000040747 |
| Bio databases IDs | |
| Aliases | CD53 antigen |
| Synonyms | CD53 antigen, CD53 molecule, LOC100363255, MOX44, OX44, TSPAN25 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd53 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tetraspanin_LEL
- protein binding activity, bridging
- protein binding
- Tetraspanin family
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- diabetic retinopathy
- peripheral arterial disease
- diabetic nephropathy
- K/BxN serum transfer arthritis
- dextran sodium sulfate-induced colitis
role in cell
- expression in
- apoptosis
- fusion
- recruitment
- transmigration
- remodeling in
- function
- remodeling
- invasiveness
- cell rolling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular structures
- cell surface
- microvesicles
- cellular membrane
- intercellular junctions
- immunological synapses
- tertiary granule membrane
- specific granule membrane
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd53 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- receptor clustering
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cell-cell junction
- synapse
- tertiary granule membrane
- plasma membrane
- immunological synapse
- specific granule membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein anchor