Pim2 Gene Summary [Mouse]
Enables protein serine/threonine kinase activity. Involved in several processes, including positive regulation of canonical NF-kappaB signal transduction; positive regulation of metabolic process; and protein stabilization. Acts upstream of or within apoptotic mitochondrial changes; negative regulation of apoptotic process; and positive regulation of macroautophagy. Predicted to be active in cytoplasm. Is expressed in several structures, including exocrine gland; genitourinary system; hemolymphoid system gland; nervous system; and nose. Orthologous to human PIM2 (Pim-2 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Pim2 |
| Official Name | proviral integration site 2 [Source:MGI Symbol;Acc:MGI:97587] |
| Ensembl ID | ENSMUSG00000031155 |
| Bio databases IDs | |
| Aliases | proviral integration site 2 |
| Synonyms | DXCch3, Pim-2 proto-oncogene, serine/threonine kinase, PLM2, Protein serine/threonine kinase, proviral integration site 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pim2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Pim2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- follicular B-cell or T-cell lymphoma
- chronic lymphocytic leukemia
- mantle cell lymphoma
- extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue
- cancer
- neoplasia
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
role in cell
- expression in
- activation in
- apoptosis
- proliferation
- production in
- growth
- survival
- morphology
- cell viability
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pim2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of macroautophagy
- negative regulation of cell proliferation
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- protein autophosphorylation
- protein phosphorylation
- response to virus
- regulation of mitotic cell cycle
- positive regulation of autophagy
- apoptotic mitochondrial changes
- positive regulation of transcription, DNA-dependent
- negative regulation of apoptotic process
- G1/S transition of mitotic cell cycle
- protein stabilization
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein serine/threonine kinase activity