Was Gene Summary [Mouse]
Enables identical protein binding activity. Acts upstream of or within several processes, including actin filament polymerization; cellular response to type II interferon; and endosomal transport. Located in cell-cell junction; phagocytic vesicle; and vesicle membrane. Is expressed in brain; heart; liver; and spleen. Used to study IgA glomerulonephritis and Wiskott-Aldrich syndrome. Human ortholog(s) of this gene implicated in Wiskott-Aldrich syndrome; X-linked severe congenital neutropenia; and thrombocytopenia. Orthologous to human WAS (WASP actin nucleation promoting factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Was |
| Official Name | Wiskott-Aldrich syndrome [Source:MGI Symbol;Acc:MGI:105059] |
| Ensembl ID | ENSMUSG00000031165 |
| Bio databases IDs | |
| Aliases | Wiskott-Aldrich syndrome |
| Synonyms | IMD2, SCNX, THC, THC1, WASP, WASPA, WASP actin nucleation promoting factor, Wiskott-Aldrich syndrome |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Was often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTPase binding domain
- GTPase regulator
- protein kinase binding
- VCA domain
- WIP binding domain
- enzyme binding
- protein binding
- Pleckstrin homology-like domain
- identical protein binding
- acidic domain
- polyproline motif
- proline rich domain
- SH3-domain binding
- phosphorylation site
- verprolin homology domain
- actin-binding domain
- WA domain
- P domain
- CRIB
- Cdc42 binding domain
- cofilin homology domain
- EVH1 domain
- basic domain
Pathways
Biological processes and signaling networks where the Was gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Axonal Guidance Signaling
- CD28 Signaling in T Helper Cells
- Cdc42 Signaling
- Ephrin Receptor Signaling
- Epithelial Adherens Junction Signaling
- FAK Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- fMLP Signaling in Neutrophils
- Integrin Signaling
- Leukocyte Extravasation Signaling
- Natural Killer Cell Signaling
- Phagosome Formation
- Regulation of Actin-based Motility by Rho
- Sertoli Cell-Sertoli Cell Junction Signaling
- Signaling by Rho Family GTPases
- Tec Kinase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Wiskott-Aldrich syndrome
- X-linked severe congenital neutropenia
- X-linked thrombocytopenia
- hereditary disorder
- hyperplasia
- chromosomal instability
- Wiskott-Aldrich syndrome 1
- thrombocytopenia
- lymphomagenesis
phenotypes
- abnormal B cell physiology
- abnormal bone marrow cell morphology/development
- abnormal cell migration
- abnormal crypts of Lieberkuhn morphology
- abnormal cytokine secretion
- abnormal dendritic cell antigen presentation
- abnormal dendritic cell morphology
- abnormal dendritic cell physiology
- abnormal double-negative T cell morphology
- abnormal double-positive T cell morphology
- abnormal glomerular mesangium morphology
- abnormal kidney morphology
- abnormal lymphocyte morphology
- abnormal mast cell morphology
- abnormal mast cell physiology
- abnormal megakaryocyte morphology
- abnormal osteoclast differentiation
- abnormal osteoclast physiology
- abnormal renal corpuscle morphology
- abnormal thymocyte activation
- colitis
- crypts of Lieberkuhn abscesses
- decreased B cell number
- decreased NK cell number
- decreased T cell number
- decreased T cell proliferation
- decreased double-positive T cell number
- decreased lymphocyte cell number
- decreased marginal zone B cell number
- decreased mature B cell number
- expanded mesangial matrix
- glomerulonephritis
- increased B cell number
- increased IgA level
- increased IgE level
- increased IgM level
- increased anti-chromatin antibody level
- increased anti-double stranded DNA antibody level
- increased anti-single stranded DNA antibody level
- increased autoantibody level
- increased follicular B cell number
- increased germinal center B cell number
- increased leukocyte cell number
- increased monocyte cell number
- increased neutrophil cell number
- increased plasma cell number
- increased splenocyte number
- increased urine protein level
- lymphoid hypoplasia
- mesangial cell hyperplasia
- renal glomerular immunoglobulin deposits
- spleen hyperplasia
- thrombocytopenia
- thymus hypoplasia
role in cell
- degranulation
- degranulation in
- recruitment in
- expression in
- activation in
- quantity
- migration
- accumulation
- transport
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- membrane fraction
- intracellular space
- perinuclear region
- pericentriolar regions
- cellular membrane
- podosomes
- actin cytoskeleton
- Nucleus
- Plasma Membrane
- actin filaments
- actin bundles
- intercellular junctions
- immunological synapses
- cytosol
- vesicle membrane
- nucleoplasm
- filopodia
- phagosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Was gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of lamellipodium assembly
- regulation of double-strand break repair via nonhomologous end joining
- macromolecular complex assembly
- actin polymerization or depolymerization
- regulation of actin polymerization or depolymerization
- actin filament polymerization
- epidermis development
- T cell activation
- regulation of stress fiber assembly
- blood coagulation
- Rho protein signal transduction
- defense response
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of stress fiber assembly
- immune response
- regulation of T cell antigen processing and presentation
- negative regulation of cell motility
- endosomal transport
- Cdc42 protein signal transduction
- cellular response to interferon-gamma
- actin filament-based movement
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- cell-cell junction
- extracellular vesicular exosome
- vesicle membrane
- actin cytoskeleton
- phagocytic vesicle
- cytosol
- actin filament
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- protein binding
- actin binding
- phospholipase binding
- small GTPase binding
- GTPase regulator activity
- SH3 domain binding