Dynlt3 Gene Summary [Mouse]
Predicted to enable dynein intermediate chain binding activity and identical protein binding activity. Predicted to be involved in microtubule-based movement and positive regulation of mitotic cell cycle. Predicted to be located in mitotic spindle astral microtubule. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in cytoplasm. Predicted to colocalize with kinetochore. Is expressed in several structures, including central nervous system; gut; lower urinary tract; nose; and submandibular gland primordium. Orthologous to human DYNLT3 (dynein light chain Tctex-type 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dynlt3 |
| Official Name | dynein light chain Tctex-type 3 [Source:MGI Symbol;Acc:MGI:1914367] |
| Ensembl ID | ENSMUSG00000031176 |
| Bio databases IDs | |
| Aliases | dynein light chain Tctex-type 3 |
| Synonyms | 2310075M16Rik, dynein light chain Tctex-type 3, RP3, TCTE1L, TCTEX1L |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dynlt3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tctex-1 family
- dynein light chain (DLC)-like domain superfamily
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Dynlt3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast adenocarcinoma
- non-insulin-dependent diabetes mellitus
- uterine leiomyoma
- leiomyomatosis
- chronic granulomatous disease
- androgenic alopecia
role in cell
- misalignment
- cell viability
- misalignment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- Nucleus
- vesicles
- centrosome
- Golgi Apparatus
- Mitochondria
- microtubules
- cytosol
- interchromatin space
- nucleoplasm
- dendritic spines
- multivesicular bodies
- smooth endoplasmatic reticulum
- astral microtubules
- plus end of microtubule
- Golgi cisternae
- PML nuclear bodies
- kinetochores
- perikaryon
- postsynaptic density
- dendritic shafts
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dynlt3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- microtubule-based movement
- positive regulation of mitotic cell cycle
- regulation of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic dynein complex
- cytoplasm
- kinetochore
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- dynein intermediate chain binding