Gpm6b Gene Summary [Mouse]
Predicted to be a structural constituent of myelin sheath. Involved in negative regulation of protein localization to cell surface and negative regulation of serotonin uptake. Located in membrane raft and plasma membrane. Is expressed in central nervous system; genitourinary system; and retina. Orthologous to human GPM6B (glycoprotein M6B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpm6b |
| Official Name | glycoprotein m6b [Source:MGI Symbol;Acc:MGI:107672] |
| Ensembl ID | ENSMUSG00000031342 |
| Bio databases IDs | |
| Aliases | glycoprotein m6b |
| Synonyms | glycoprotein M6B, Gpm6, M6B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpm6b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Myelin proteolipid protein (PLP or lipophilin)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- astrocytosis
- microgliosis
- psoriasis
- atrial fibrillation
- COVID-19
- idiopathic pulmonary fibrosis
- hypertonia
- tremor
- open-angle glaucoma
regulates
- cholesterol
- 5-hydroxytryptamine
role in cell
- apoptosis
- organization
- abnormal morphology
- assembly
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpm6b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system myelination
- negative regulation of protein localization at cell surface
- regulation of focal adhesion assembly
- regulation of actin cytoskeleton organization
- ossification
- protein transport
- nervous system development
- extracellular matrix assembly
- positive regulation of bone mineralization
- negative regulation of serotonin uptake
Cellular Component
Where in the cell the gene product is active
- myelin sheath
- membrane raft
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- structural constituent of myelin sheath