Proz Gene Summary [Mouse]
Predicted to enable serine-type endopeptidase activity. Acts upstream of or within blood coagulation. Located in extracellular region. Is expressed in liver and plasma. Human ortholog(s) of this gene implicated in Behcet's disease and brain ischemia. Orthologous to human PROZ (protein Z, vitamin K dependent plasma glycoprotein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Proz |
| Official Name | protein Z, vitamin K-dependent plasma glycoprotein [Source:MGI Symbol;Acc:MGI:1860488] |
| Ensembl ID | ENSMUSG00000031445 |
| Bio databases IDs | |
| Aliases | protein Z, vitamin K-dependent plasma glycoprotein |
| Synonyms | 1300015B06Rik, Protein Z, protein Z, vitamin K-dependent plasma glycoprotein, PZ, Vitamin K-dependent protein Z |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Proz often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- Tryp_SPc
- peptidase
- Human growth factor-like EGF
- calcium ion binding
- protein binding
- Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
- Coagulation Factor Xa inhibitory site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- hepatocellular carcinoma
- organismal death
- diabetic nephropathy
- hepatitis B virus-related hepatocellular carcinoma
- aortic valve calcification
- thrombosis
- bleeding
- deficiency of protein z
role in cell
- expression in
- proliferation
- migration
- phosphorylation in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- endoplasmic reticulum lumen
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Proz gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- blood coagulation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- Golgi lumen
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- serine-type endopeptidase activity