Dkk4 Gene Summary [Mouse]
Predicted to enable co-receptor binding activity and receptor antagonist activity. Acts upstream of or within Wnt signaling pathway and negative regulation of hair follicle placode formation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human DKK4 (dickkopf WNT signaling pathway inhibitor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dkk4 |
| Official Name | dickkopf WNT signaling pathway inhibitor 4 [Source:MGI Symbol;Acc:MGI:2385299] |
| Ensembl ID | ENSMUSG00000031535 |
| Bio databases IDs | |
| Aliases | dickkopf WNT signaling pathway inhibitor 4 |
| Synonyms | dickkopf WNT signaling pathway inhibitor 4, RGD1563172 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dkk4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Colipase and the second cysteine-rich (Cys-2) domain of Dickkopf proteins
- protein binding
- first cysteine-rich (Cys-1) domain of Dickkopf proteins
Pathways
Biological processes and signaling networks where the Dkk4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- colorectal cancer
- survival
role in cell
- apoptosis
- expression in
- proliferation
- differentiation
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dkk4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway
- negative regulation of hair follicle placode formation
- negative regulation of Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor antagonist activity