DKK4
DKK4 Gene Summary
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | DKK4 |
| Official Name | dickkopf WNT signaling pathway inhibitor 4 [Source:HGNC Symbol;Acc:HGNC:2894] |
| Ensembl ID | ENSG00000104371 |
| Bio databases IDs | |
| Aliases | dickkopf WNT signaling pathway inhibitor 4 |
| Synonyms | dickkopf WNT signaling pathway inhibitor 4,RGD1563172 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Colipase and the second cysteine-rich (Cys-2) domain of Dickkopf proteins
- protein binding
- first cysteine-rich (Cys-1) domain of Dickkopf proteins
Pathways
Biological processes and signaling networks where the DKK4 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- LRP5
- OPTN
- RNPEPL1
- CTNNB1
- TSPO2
- UBR2
- CUL1
- IDE
- ITGAM
- LARP1
disease
- metastasis
- colorectal cancer
- survival
regulated by
- LEF1
- WNT3A
- mir-450 (includes others)
- EOMES
- CTNNB1
- L-triiodothyronine
- LARP1
- DICER1
- STAT5B
- lithium chloride
regulates
- MMP2
- ALP
- AKT2
- AXIN2
- CTNNB1
- FZD6
- MMP3
- JUN
- NKD1
- NLK
role in cell
- apoptosis
- expression in
- proliferation
- differentiation
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the DKK4 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway
- negative regulation of hair follicle placode formation
- negative regulation of Wnt receptor signaling pathway
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- receptor antagonist activity