Lpar2 Gene Summary [Mouse]
Enables PDZ domain binding activity. Acts upstream of or within G protein-coupled receptor signaling pathway; positive regulation of MAPK cascade; and positive regulation of Rho protein signal transduction. Is active in glutamatergic synapse and presynaptic active zone membrane. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; hemolymphoid system gland; and sensory organ. Orthologous to human LPAR2 (lysophosphatidic acid receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lpar2 |
| Official Name | lysophosphatidic acid receptor 2 [Source:MGI Symbol;Acc:MGI:1858422] |
| Ensembl ID | ENSMUSG00000031861 |
| Bio databases IDs | |
| Aliases | lysophosphatidic acid receptor 2 |
| Synonyms | EDG-4, IPA2, LPA-2, LPA2 receptor, LPA receptor 2, lysophosphatidic acid receptor 2, RGD1561336 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lpar2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- lipid binding
- CXXC zinc finger
- 7 transmembrane receptor (rhodopsin family)
- tail domain
- protein binding
- PDZ binding motif
- seven-transmembrane G protein-coupled receptor superfamily
- PDZ-domain binding
Pathways
Biological processes and signaling networks where the Lpar2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- idiopathic pulmonary fibrosis
- rhabdomyosarcoma
- soft tissue sarcoma cancer
- intimal hyperplasia
- hypersensitivity reaction type I
- cardiac fibrosis
- enteropathy
- gastric cancer
role in cell
- recruitment
- apoptosis
- expression in
- growth
- migration
- proliferation
- activation in
- formation
- cell death
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- cell surface
- cellular membrane
- cytosol
- presynaptic membrane
- endocytotic vesicle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lpar2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Rho protein signal transduction
- G-protein coupled receptor signaling pathway
- regulation of metabolic process
- positive regulation of MAPK cascade
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- endocytic vesicle
- cytoplasm
- presynaptic active zone membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- lysophosphatidic acid receptor activity
- G-protein coupled receptor activity
- protein binding
- PDZ domain binding
- lipid binding