Jam3 Gene Summary [Mouse]
Enables identical protein binding activity and integrin binding activity. Involved in angiogenesis; cell-cell adhesion; and hematopoietic stem cell migration to bone marrow. Acts upstream of or within several processes, including leukocyte migration involved in inflammatory response; myeloid progenitor cell differentiation; and regulation of actin cytoskeleton organization by cell-cell adhesion. Located in Schmidt-Lanterman incisure; bicellular tight junction; and paranodal junction. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Orthologous to human JAM3 (junctional adhesion molecule 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Jam3 |
| Official Name | junction adhesion molecule 3 [Source:MGI Symbol;Acc:MGI:1933825] |
| Ensembl ID | ENSMUSG00000031990 |
| Bio databases IDs | |
| Aliases | junction adhesion molecule 3 |
| Synonyms | 1110002N23Rik, JAM-2, JAM-C, Jcam3, junction adhesion molecule 3, junctional adhesion molecule 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Jam3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Immunoglobulin V-Type
- immunoglobulin domain
- cell adhesion molecule binding
- Ig-like C2 domain
- ectodomain
- Immunoglobulin I-set domain
- protein binding
- Par3 binding domain
- identical protein binding
- Ig-like V domain
- integrin binding
- Immunoglobulin like
- cytosolic tail domain
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the Jam3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- K/BxN serum transfer arthritis
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- breast carcinoma
- endometrial cancer
- hemorrhagic destruction of the brain, subependymal calcification, and cataracts
- schizophrenia
- rheumatoid arthritis
- hypersensitive reaction
role in cell
- number
- apoptosis
- expression in
- quantity
- transendothelial migration
- differentiation
- cellular infiltration by
- phosphorylation in
- migration
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- apical ectoplasmic specialization
- cell junction
- cell surface
- cell borders
- Extracellular Space
- cellular membrane
- Golgi Apparatus
- actin filaments
- intercellular junctions
- desmosomes
- cell-cell contacts
- lateral cell surfaces
- plasma membrane projections
- nodes of Ranvier
- paranodes
- paranodal junctions
- outer mesaxons
- inner mesaxons
- Schmidt-Lanterman incisures
- anchoring junction
- tight junctions
- microvilli
- cell-cell adherens junctions
- motor axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Jam3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- protein localization at cell surface
- regulation of actin cytoskeleton organization by cell-cell adhesion
- spermatid development
- regulation of neutrophil chemotaxis
- adaptive immune response
- myelination
- neutrophil homeostasis
- hematopoietic stem cell migration to bone marrow
- negative regulation of cell adhesion mediated by integrin
- positive regulation of monocyte extravasation
- leukocyte migration involved in inflammatory response
- angiogenesis
- myeloid progenitor cell differentiation
- apical protein localization
- establishment of cell polarity
- adherens junction assembly
- heterotypic cell-cell adhesion
- transmission of nerve impulse
- cell migration
- negative regulation of integrin activation
- maintenance of blood-brain barrier
Cellular Component
Where in the cell the gene product is active
- paranodal junction
- Golgi apparatus
- plasma membrane
- cell-cell contact zone
- extracellular space
- occluding junction
- tight junction
- cell-cell junction
- microvillus
- Schmidt-Lanterman incisure
- desmosome
- filamentous actin
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- protein heterodimerization activity
- integrin binding