Lcat Gene Summary [Mouse]
Enables phosphatidylcholine-sterol O-acyltransferase activity and platelet-activating factor acetyltransferase activity. Involved in regulation of high-density lipoprotein particle assembly. Acts upstream of or within cholesterol metabolic process and lipoprotein biosynthetic process. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and integumental system. Used to study Norum disease. Human ortholog(s) of this gene implicated in Norum disease and arteriosclerosis. Orthologous to human LCAT (lecithin-cholesterol acyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lcat |
| Official Name | lecithin cholesterol acyltransferase [Source:MGI Symbol;Acc:MGI:96755] |
| Ensembl ID | ENSMUSG00000035237 |
| Bio databases IDs | |
| Aliases | lecithin cholesterol acyltransferase |
| Synonyms | D8Wsu61e, Lecithin Acyltransferase, lecithin-cholesterol acyltransferase, PHOSPHATIDYLCHOLINE STEROL ACYLTRANSFERASE |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lcat often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatidylcholine-sterol O-acyltransferase
- 1-alkyl-2-acetylglycerophosphocholine esterase
- sterol esterase
- alpha/beta hydrolases
- enzyme
- protein binding
- Lecithin:cholesterol acyltransferase
- platelet-activating factor acetyltransferase
- phospholipase A2
Pathways
Biological processes and signaling networks where the Lcat gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hemolytic anemia
- liver cancer
- lecithin acyltransferase deficiency
- fish-eye disease
- esophageal adenocarcinoma
- esophageal carcinoma formation
- epithelial cancer
- chronic renal failure
- obesity
role in cell
- quantity
- proliferation
- expression in
- cellular infiltration by
- morphology
- colony formation by
- assembly
- hypertrophy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lcat gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- very-low-density lipoprotein particle remodeling
- regulation of high-density lipoprotein particle assembly
- high-density lipoprotein particle remodeling
- cholesterol metabolic process
- lipoprotein biosynthetic process
- phospholipid metabolic process
- cholesterol homeostasis
- phosphatidylcholine biosynthetic process
- phosphatidylcholine metabolic process
- reverse cholesterol transport
- lipid metabolic process
- cholesterol transport
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- high-density lipoprotein particle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- platelet-activating factor acetyltransferase activity
- phosphatidylcholine-sterol O-acyltransferase activity
- 1-alkyl-2-acetylglycerophosphocholine esterase activity
- apolipoprotein A-I binding
- sterol esterase activity