Ephb1 Gene Summary [Mouse]
Enables axon guidance receptor activity. Involved in several processes, including dendritic spine morphogenesis; detection of temperature stimulus involved in sensory perception of pain; and negative regulation of satellite cell differentiation. Acts upstream of or within several processes, including axonogenesis; ephrin receptor signaling pathway; and optic nerve morphogenesis. Located in several cellular components, including axon; filopodium tip; and membrane raft. Is active in glutamatergic synapse. Is expressed in several structures, including 1st branchial arch; brain; sensory organ; urogenital sinus; and vascular system. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human EPHB1 (EPH receptor B1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ephb1 |
| Official Name | Eph receptor B1 [Source:MGI Symbol;Acc:MGI:1096337] |
| Ensembl ID | ENSMUSG00000032537 |
| Bio databases IDs | |
| Aliases | Eph receptor B1 |
| Synonyms | 9330129L11, C130099E04Rik, Cek6, Efnb1r, ELK, ELKH, Ephb2, Ephbi, EPH receptor B1, Eph receptor b2, EPHT2, Erk, Hek6, NET |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ephb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Ligand Binding Domain of Ephrin Receptors
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- axon guidance receptor
- SAM (Sterile alpha motif )
- SAM domain
- protein binding
- Fibronectin type 3 domain
- protein-tyrosine kinase
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Sterile alpha motif
- transmembrane-ephrin receptor
- binding protein
- Protein Kinases, catalytic domain
- Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
- cytoplasmic domain
- FN3
- SAM domain (Sterile alpha motif)
- Tyrosine kinase, catalytic domain
- Ephrin receptor ligand binding domain
Pathways
Biological processes and signaling networks where the Ephb1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung carcinoma
- lung carcinoma process
- cutaneous melanoma
- cutaneous melanoma cancer
- metabolic syndrome X
- lung adenocarcinoma
- lung adenocarcinoma formation
- neuroticism
- chronic pain
- insomnia
role in cell
- differentiation
- proliferation
- binding in
- adhesion
- migration
- cell viability
- expression in
- recruitment in
- formation
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic plasma membrane fractions
- glutaminergic synapse
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- cytosol
- presynaptic membrane
- postsynaptic membrane
- endosomal membrane
- dendritic spines
- synapse
- membrane rafts
- filopodia
- filopodial tip
- axons
- dendrites
- postsynaptic density
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ephb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- hindbrain tangential cell migration
- neural precursor cell proliferation
- axon guidance
- central nervous system projection neuron axonogenesis
- protein autophosphorylation
- neurogenesis
- protein phosphorylation
- immunological synapse formation
- cell chemotaxis
- optic nerve morphogenesis
- angiogenesis
- satellite cell activation
- positive regulation of synapse assembly
- retinal ganglion cell axon guidance
- dendritic spine development
- regulation of JNK cascade
- dendritic spine morphogenesis
- regulation of ERK1 and ERK2 cascade
- camera-type eye morphogenesis
- ephrin receptor signaling pathway
- establishment of cell polarity
- regulation of synaptic transmission
- cell-substrate adhesion
- detection of temperature stimulus involved in sensory perception of pain
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- dendrite
- extracellular vesicular exosome
- membrane raft
- cytosol
- filopodium tip
- endoplasmic reticulum
- extracellular region
- plasma membrane
- axon
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- axon guidance receptor activity
- transmembrane-ephrin receptor activity