Srxn1 Gene Summary [Mouse]
Enables oxidoreductase activity, acting on a sulfur group of donors. Involved in response to oxidative stress. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in adrenal medulla and embryo. Orthologous to human SRXN1 (sulfiredoxin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Srxn1 |
| Official Name | sulfiredoxin 1 homolog (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:104971] |
| Ensembl ID | ENSMUSG00000032802 |
| Bio databases IDs | |
| Aliases | sulfiredoxin 1 homolog (S. cerevisiae) |
| Synonyms | 1700127B04RIK, Ab2-390, AI854065, C20orf139, Neoplastic progression 3, Npn3, SRX, SRX1, sulfiredoxin 1, sulfiredoxin 1 homolog (S. cerevisiae), sulphiredoxin 1, sulphiredoxin 1 homolog (S. cerevisiae), TX01 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Srxn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ParB/Sulfiredoxin domain
- ParB N-terminal domain and sulfiredoxin protein-related families
- sulfur group oxidoreductase
- enzyme
- antioxidant enzyme
- protein binding
- ParB-like nuclease domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- HER2 negative hormone receptor negative breast cancer
- organismal death
- obesity
- actinic keratosis
role in cell
- expression in
- apoptosis
- transmembrane potential
- production in
- reduction in
- glutathionylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Srxn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- cellular response to oxidative stress
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- oxidoreductase activity, acting on a sulfur group of donors
- ATP binding
- protein binding
- sulfiredoxin activity